Similarity-Based Multimarker Association Tests for Continuous Traits
نویسندگان
چکیده
منابع مشابه
Family-Based Bivariate Association Tests for Quantitative Traits
The availability of a large number of dense SNPs, high-throughput genotyping and computation methods promotes the application of family-based association tests. While most of the current family-based analyses focus only on individual traits, joint analyses of correlated traits can extract more information and potentially improve the statistical power. However, current TDT-based methods are low-...
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The data from genome-wide association studies (GWAS) in humans are still predominantly analyzed using single-marker association methods. As an alternative to single-marker analysis (SMA), all or subsets of markers can be tested simultaneously. This approach requires a form of penalized regression (PR) as the number of SNPs is much larger than the sample size. Here we review PR methods in the co...
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Although traditional case-control studies may be subject to bias caused by population stratification, alternative methods that are robust to population stratification such as family-based association designs may be less powerful due to overmatching between cases and controls. Furthermore, case-control studies have the advantages of easy sample collection. Recently, several statistical methods h...
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ژورنال
عنوان ژورنال: Annals of Human Genetics
سال: 2012
ISSN: 0003-4800
DOI: 10.1111/j.1469-1809.2012.00706.x